Our Portfolio

Integrated Approach for Cost Reduction

M4ALL’s unique approach combines novel chemistry with the fundamental elements of process intensification. These elements include:

• Vertical integration of advanced starting materials prepared from commodity chemicals
• Consolidation of high-yielding reactions into a minimal number of unit operations with common solvents and limited intermediate isolations
• Evaluation of alternative manufacturing platforms.

 Paper Study

Paper studies enable the initial step toward establishing a benchmark of the current commercial process of a target and identifying potential cost drivers that will drive generation of strategies for cost reduction.

 Synthesis & Route Scouting

Design, develop, and implement novel & alternative synthetic routes to address primary cost drivers.

 Optimization & Multi-gram Scale up

Optimization and multi-gram synthesis of the high-yielding and cost-effective routes.

 Market Engagement and Technology Transfer

Outreach to manufacturing to implement M4ALL processes.

 Market Surveillance

Tracking of the market after release and implementation of M4ALL processes.

M4ALL has created and successfully utilized a new, integrated approach that targets those existing or novel treatments in which transformations would most positively impact global health, and ensures that M4ALL’s optimized processes can be readily translated into existing sourcing and procurement processes for immediate cost savings.

M4ALL is working with a number of global health partners and pharmaceutical companies to increase access to critical medicines through its creative approach to synthetic chemistry and process innovation. We attract chemists and engineers from around the globe to bring their talents to our labs in Richmond, Virginia. They devote their scientific and creative energies to finding improvements for the drug targets we are asked to evaluate. Our partners include foundations, corporations, non-profits and governments interested in seeing how the techniques M4ALL employs can reduce costs and cut waste.