A Concise Route to Molnupiravir (MK-4482) from Cytidine (Acetonide)



A new route to MK-4482 was developed. The route replaces uridine with the more available and less expensive cytidine. Low-cost, simple reagents are used for the chemical transformations, and the yield is improved from 17% to 44%. A step is removed from the longest linear sequence, and these advancements are expected to expand access to MK-4482 should it become a viable drug substance.

A Concise Route to MK-4482 (EIDD-2801) from Cytidine: Part 2