OPC-167832
M4ALL developed a concise process to prepare the key dihydroquinolone intermediate used to make the API by using commodity raw materials.
Alternative Intermediate Synthesis
Route Improvements
- The M4AII synthesis provides greatly improved scalable access to the key intermediate from readily available starting materials in high yield and purity.
- The key feature of this process is the development of a telescoped one-pot synthesis of the quinolone in a sequence of amidation/cyclization reactions
Development of a Practical Synthesis of the 8-FDC Fragment of OPC-167832