Supplementary Information for PHT Process

GC-HS Method Description for Residual Solvents in TGF-001

GC-HS Method Limited Verification for Residual Solvents in TGF-001 (non-GMP)

HPLC Method Desc. for ID, Assay, Rel Sub of PNDa01 & PNDa06-HCl

HPLC Method Description for Identity, Assay and Related Substances of PNDa02

HPLC Method Description for Identity, Assay and Related Substances of TGF-001

HPLC Method Description for In-process Control of Intermediates

HPLC Method Limited Verification for PNDa01 and PNDa06-HCl (non-GMP)

HPLC Method Limited Verification for PNDa02 (non-GMP)

HPLC Method Limited Verification for TGF-001 (non-GMP)

PHT Final Report Pyronaridine Tetraphosphate