(R)-3-aminobutanol (Batch)
Intermediate
Summary
A one-step synthesis of optically active (R)-3-aminobutan-1-ol from commercially available starting materials is described. This product is a key raw material used in the production of dolutegravir. Our process reduces (R)-3-aminobutanoic acid using the low-cost reducing agent sodium aluminum hydride. The approach provides isolated yields ranging from 61-67% with purity ranging from 96-99% and optical purity at 100% based on three 20 gram scale runs.
